Double Marker test

What is a Double Marker Test?

The Double Marker Test, also referred to as the dual marker test, is a blood test done during the first trimester of pregnancy, typically between weeks 11 and 14. It is used to screen for chromosomal abnormalities in the fetus, such as Down syndrome (Trisomy 21) and Trisomy 18.

This test measures two key substances in the mother’s blood:

• Free Beta-hCG (human chorionic gonadotropin): a hormone produced during pregnancy
• PAPP-A (pregnancy-associated plasma protein-A): a protein produced by the placenta

The results are interpreted alongside the Nuchal Translucency (NT) scan, which measures fluid at the back of the baby's neck via ultrasound. Together, these provide a combined risk assessment without harming the mother or baby.

The double marker test is a screening tool, not a diagnostic test—it indicates the likelihood of certain conditions, not a definitive diagnosis.

Importance of a Double Marker Test 

The Double Marker Test plays a vital role in assessing the genetic health of the fetus early in pregnancy. It helps identify the risk of chromosomal abnormalities, allowing expecting parents and doctors to take timely decisions regarding further testing and care.

Early Detection of Genetic Conditions

This test helps screen for common chromosomal disorders such as:

• Down syndrome (Trisomy 21)
• Trisomy 18, which can lead to severe developmental delays or miscarriage

Detecting these risks early allows for timely confirmatory tests, such as Non-Invasive Prenatal Testing (NIPT) or amniocentesis, if needed.

Safe and Non-Invasive

The test involves only a blood sample from the mother and does not pose any risk to the fetus. When combined with the NT scan, it enhances the accuracy of screening.

Informed Pregnancy Planning

For parents, knowing the risk level of genetic abnormalities helps in planning and managing the pregnancy with appropriate medical guidance and support.

Who Should Get a Double Marker Test?

The Double Marker Test is generally recommended for all pregnant women as part of routine first-trimester screening. However, it becomes particularly important for individuals who may have a higher risk of chromosomal abnormalities.

Recommended for:

• Pregnant women above 35 years of age, as advancing maternal age is linked to a higher likelihood of chromosomal abnormalities.
• Those with a family history of genetic disorders or previous pregnancies affected by chromosomal conditions
• Expecting mothers with abnormal NT scan results, which may suggest increased fluid at the back of the baby’s neck
• Women with pre-existing medical conditions, such as diabetes or autoimmune disorders, which may affect pregnancy outcomes
• Anyone advised by their gynaecologist based on medical history or ultrasound findings

The test helps provide peace of mind or early awareness, depending on the results, and ensures better preparedness for the next steps in prenatal care.

Common Concerns Addressed by the Double Marker Test

The Double Marker Test helps address several important concerns during early pregnancy, particularly those related to the baby’s genetic health and the mother’s individual risk factors.

Age-Related Genetic Risks

Women over the age of 35 have a higher likelihood of chromosomal abnormalities in pregnancy. The double marker test helps assess this risk early, even in the absence of symptoms or family history.

Family History of Genetic Disorders

For those with a history of inherited conditions, this test can offer an early indication of whether additional genetic testing may be needed.

Abnormal NT Scan Findings

If the Nuchal Translucency (NT) scan shows a thicker-than-usual fluid measurement at the back of the baby’s neck, the double marker test helps clarify whether there's an elevated risk for chromosomal conditions.

Pregnancy After IVF or Assisted Reproduction

In cases of assisted pregnancy, early risk screening is often recommended to ensure everything is progressing safely.

By providing a non-invasive risk assessment, the double marker test supports better decision-making and early intervention, when necessary.

Double Marker Test Procedure and Sample Collection

The Double Marker Test is a simple, safe, and non-invasive procedure that requires only a blood sample from the mother. It is usually performed between 11 to 14 weeks of pregnancy, often in combination with the Nuchal Translucency (NT) scan.

How the Test is Done

A trained professional collects a blood sample from a vein in the arm. The blood is then analysed to measure the levels of two key markers—Free Beta-hCG and PAPP-A. These values, along with NT scan findings and maternal age, are used to calculate the risk of chromosomal abnormalities in the fetus.

Home Sample Collection with MaxAtHome

MaxAtHome offers a comfortable and stress-free testing experience by providing:

• Free home sample collection at a time convenient for the patient
• Certified phlebotomists who follow strict hygiene protocols
• No need to visit a clinic or hospital, making it ideal for expectant mothers

The process is quick and usually takes just a few minutes, with all precautions taken to ensure safety and comfort.

Fasting Requirements and Report Availability

Is Fasting Required?

No, fasting is not required before taking the Double Marker Test. Expectant mothers can eat and drink normally unless otherwise advised by their doctor.

Report Availability

MaxAtHome ensures timely access to results for prompt follow-up and decision-making.

• Test reports are available online within 24 hours of sample collection
• Reports can be accessed securely through the MaxAtHome website or mobile app
• In case of elevated risk, follow-up consultation with a specialist is recommended

Fast reporting allows for early review of results and further planning, if necessary, without unnecessary delays during this critical phase of pregnancy.

Understanding Double Marker Test Results

The Double Marker Test provides a risk assessment, not a definitive diagnosis. It helps estimate the likelihood of certain chromosomal abnormalities in the fetus, based on the levels of Free Beta-hCG and PAPP-A, along with NT scan measurements and maternal age.

Interpreting the Results

The outcome is usually reported as either:

• Screen Negative (Low Risk): Indicates a lower probability of conditions such as Down syndrome or Trisomy 18.
• Screen Positive (High Risk): Indicates a higher-than-average risk and may warrant further diagnostic tests like NIPT, CVS, or amniocentesis.

Double Marker Test Normal Range

While exact values may vary by lab, general patterns include:

• High Beta-hCG + Low PAPP-A: May indicate increased risk of Down syndrome
• Both markers low: May suggest risk of Trisomy 18
• Values within normal range typically indicate a low-risk result

The doctor considers these values along with NT scan, age, and medical history of the patient to recommend the next steps.

Cost and Availability of the Double Marker Test

MaxAtHome offers a reliable and accessible way to undergo the Double Marker Test without the need to visit a clinic. The service is designed to provide convenience, accuracy, and value for expectant mothers seeking early screening.

Factors Affecting the Price of Home Testing

The cost of the test may vary based on:

• The city or location where the test is booked
• Whether it is taken as an individual test or part of a prenatal screening package
• Applicable home collection charges (offered free by MaxAtHome)
• Ongoing offers or seasonal health packages

Despite these variables, MaxAtHome ensures transparent pricing with no hidden costs, making it easier for families to access essential prenatal care.

How to Book the Double Marker Test with MaxAtHome

Booking the Double Marker Test through MaxAtHome is easy, fast, and completely home-based—ideal for expectant mothers seeking a stress-free experience.

Follow these simple steps to get started:

1. Schedule the test online through our easy-to-use booking platform.
2. Select your location and preferred date for home sample collection.
3. Enter the required details and confirm your booking online.
4. A trained professional will visit your home at the scheduled time to collect the blood sample.
5. Access your digital test report within 24 hours through the MaxAtHome website or app.

For any assistance with booking or queries, you can also call the MaxAtHome customer care team at 01244781023.